Toxoplasma gondii: susceptibility and development of resistance to anticoccidial drugs in vitro
نویسندگان
چکیده
منابع مشابه
Toxoplasma gondii: susceptibility and development of resistance to anticoccidial drugs in vitro.
Anticoccidial drugs were evaluated for activity and for the development of resistance in a model of Toxoplasma gondii growing in human fibroblast cultures. Of 13 anticoccidial drugs tested, 9 had selective antitoxoplasma activity (50% inhibitory concentration, in micrograms per milliliter): decoquinate (0.005), arprinocid-N-oxide (0.015), robenidine (0.03), the aryl triazine CP-25,415 (0.2), to...
متن کاملStudy of resistance to Toxoplasmosis using Tachizoites surface antigens of Toxoplasma gondii in vivo
Taoxoplasma gondii is an important food-borne parasite transmitted primarily from animals to humans through meat consumption, mainly pork and lamb, as well as through oocysts shed by cats. Infection in humans can cause severe fetal malformations, ocular complications or encephalitis. Toxoplasmosis infection during pregnancy, especially in sheep, often results in abortion, representing considera...
متن کاملIn vitro susceptibility of various genotypic strains of Toxoplasma gondii to pyrimethamine, sulfadiazine, and atovaquone.
Sulfadiazine, pyrimethamine, and atovaquone are widely used for the treatment of severe toxoplasmosis. Their in vitro activities have been almost exclusively demonstrated on laboratory strains belonging to genotype I. We determined the in vitro activities of these drugs against 17 strains of Toxoplasma gondii belonging to various genotypes and examined the correlations among 50% inhibitory conc...
متن کاملToxoplasma gondii in vitro cultivation: propagation
Based on a serum-free and CO,-independent culture of Toxoplasma gondii in vitro, a long-term propagation of a highly virulent strain of this parasite was developed. Toxoplasma monolayer cultures were fed on a weekly cycle with native host cells (HEp-2) while changing the medium, thus simultaneously removing cell debris and just bred trophozoites. Establishing this method was of low effort in or...
متن کاملInflammasome Sensor NLRP1 Controls Rat Macrophage Susceptibility to Toxoplasma gondii
Toxoplasma gondii is an intracellular parasite that infects a wide range of warm-blooded species. Rats vary in their susceptibility to this parasite. The Toxo1 locus conferring Toxoplasma resistance in rats was previously mapped to a region of chromosome 10 containing Nlrp1. This gene encodes an inflammasome sensor controlling macrophage sensitivity to anthrax lethal toxin (LT) induced rapid ce...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1993
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.37.11.2358